The Riggs-Gelasco Lab
STRUCTURAL STUDIES OF NON-HEME METALLOENZYME INTERMEDIATES
Pamela Riggs-Gelasco
Ph.D., University of Michigan, Ann Arbor, 1995
Asociate Professor of Chemistry & Biochemistry
Chemistry & Biochemistry
College of Charleston
66 George Street
Charleston, SC 29424
Office: Rita Liddy Hollings Science Center, Rm 305
Email: gelascop@cofc.edu
Phone: 843-953-7182
Fax: 843-953-1404
The Riggs-Gelasco laboratory uses x-ray absorption spectroscopy to determine the active site structure of metalloenzymes.
Current Research
Dr. Riggs-Gelasco has been funded as the PI on grants from the American Chemical Society-PRF, from the State of South Carolina Committee on Higher Education, and from the Dreyfus Foundation. One biochemistry project in her lab has been funded by NIGMS at the National Institutes of Health. In addition, she has been the PI on several proposals to national synchrotron facilities to obtain experimental time for X-ray absorption experiments.
She has an ongoing interest in the following systems:
- Metal Specificity of ribonucleotide reductases
- Catalytic site of manganese oxidizing proteins
- Characterization of reaction intermediates in non-heme Fe enzymes
- Sulfur oxidation in biological systems
- Characterization of the metal center in the Pfiesteria Piscicidaichthyotoxin
- Heavy metal accumulation in Acanthocephalans
Lab Students
Past and Present Lab Members (click photos to enlarge)
Seth Bowman (’06):
Seth worked in the lab during the Spring and Summer of
2005. A Biochemistry major, he graduated with a BS, summa cum laude, in
May of 2006. His entrance to medical school is pending.
Jolene Duncan-Gould (’05):
Jolene worked in the lab in the Spring and summer of 2005. She graduated in May
of 2005 with her degree in Biochemistry. She was inducted into Phi Kappa Phi.
She presented her research, "Cloning, Overexpression and Purification of Manganese
Catalase from
Lactobacillus Plantarum," at the SMM Poster Sessions in April of 2005.
Alan Wilder (’06):
Summer 2005, Fall 2005 (Grad School Pending)
David Lane — Fall 2005
Ryan Yonce — Ryan began in
the lab in the Summer of 2006. He is
working on the ribonucleotide reductase project and on XAS of non-heme iron
proteins. He is graduating in the Spring of 2007 and plans to attend
graduate school after taking a year off.
Amy Rhoden — Amy began in
the lab in the Summer of 2006. She is working on the ribonucleotide
reductase project and on XAS of non-heme iron proteins. Amy graduates in Spring
2008 and is currently undecided on her future plans (medical school or graduate
school).
Alix Grimley — Alix has
worked in the lab since the Summer of 2006. She is working on the
manganese catalase project. She
is
graduating spring of 2007. She is currently working on writing her bachelor’s
essay for the Honor’s program. She is applying for graduate programs
for the Fall of ’07.
Matt Williams — Matt started in the lab in the Summer of 2006. He is working on the ribonucleotide reductase project. He graduates in Spring of 2008. He is planning on going to Pharmacy School.