Research
Student Projects:
Current Projects:
Top: Drew Philipp
Bottom: George Miller
Recent Projects:
Bottom Left: Danielle Adler
Bottom Right: Catherine Kramp
RECENT PUBLICATIONS
1) Agnes Ayme-Southgate, Judith Saide, Richard Southgate, Christophe Bounaix, Anthony Cammarato, Sunita Patel and Catherine Wussler. (2006) In Indirect Flight Muscles Drosophila Projectin has a short PEVK domain, and its NH2-terminus is embedded at the Z-band. J. Muscle Res. Cell Mot. Feb 8:1-11
2) Agnes Ayme-Southgate, Christophe Bounaix, Theresa E. Riebe and Richard Southgate. (2004) Assembly of the Giant Protein Projectin During Myofibrillogenesis in Drosophila Indirect Flight Muscles. Bio Med Central Cell Biol. 5:17 (30 Apr 2004)
OPEN ACCESS: http://www.biomedcentral.com/1471-2121/5/17
3) Ayme-Southgate, A. and Southgate, R. (2004) Projectin, the elastic protein of the C-filaments. In "Nature's versatile Engine: Insect Flight Muscle Inside and Out". Ed. Vigoreaux, J. ; Landes Bioscience Publishers. in press
1) Agnes Ayme-Southgate, Judith Saide, Richard Southgate, Christophe Bounaix, Anthony Cammarato, Sunita Patel and Catherine Wussler. (2006) In Indirect Flight Muscles Drosophila Projectin has a short PEVK domain, and its NH2-terminus is embedded at the Z-band. J. Muscle Res. Cell Mot. Feb 8:1-11
2) Agnes Ayme-Southgate, Christophe Bounaix, Theresa E. Riebe and Richard Southgate. (2004) Assembly of the Giant Protein Projectin During Myofibrillogenesis in Drosophila Indirect Flight Muscles. Bio Med Central Cell Biol. 5:17 (30 Apr 2004)
OPEN ACCESS: http://www.biomedcentral.com/1471-2121/5/17
3) Ayme-Southgate, A. and Southgate, R. (2004) Projectin, the elastic protein of the C-filaments. In "Nature's versatile Engine: Insect Flight Muscle Inside and Out". Ed. Vigoreaux, J. ; Landes Bioscience Publishers. in press
- Flight muscles are classified as either synchronous or asynchronous. On this phylogeny [left] (adapted from Wheeler et al 2001), the occurrence of asynchronous flight is highlighted. One observation is that asynchronous physiology either evolved multiple times or evolved and was subsequently lost in some groups. Lab projects are focused on the evolution of specific myofibrillar proteins in relation with flight physiology.
- Asynchrony depends on the mechanism of "delayed stretch activation". The current model proposes that stretch modifies the myofibrillar structure leading to increase in recruitable myosin heads. C-filament may provide some of the necessary stiffness as well as possible interactions with myosin rods (see projectin project).
-Asynchrony also occurs at constant cytosolic calcium concentration. The distribution and isoforms of several calcium-binding proteins could, therefore, also be affected (see mp20 project).
